24 March 2010

Gene Linked to Lung Cancer Risk in Non-Smokers

Business Week
Discovery could provide target for future treatments, researchers say


Researchers have identified gene variations linked with an increased risk for lung cancer in people who have never smoked.

The international research team analyzed DNA from more than 1,000 people with lung cancer and cancer-free people who had never smoked and found strong evidence that two variations in a gene called GPC5 were associated with lung cancer in people who had never smoked. The variations reduce expression of GPC5, the study authors explained.

Further investigation revealed that GPC5 expression levels were 50 percent lower in lung cancer tissue from people who had never smoked, compared with lung tissue from cancer-free non-smokers.

The findings suggest that GPC5 could be a new target for further research and drug development and could be used to identify non-smokers at high risk for St Louis lung cancer treatment.

The study findings are published online in The Lancet Oncology.

"Even though this study reports a two-fold reduction in GPC5 expression in [lung cancer] tissues compared to matched normal controls, it is far from clear how reduced GPC5 expression could predispose individuals to lung cancer," Dr. Ramaswamy Govindan, of Washington University School of Medicine in St. Louis cancer specialists, wrote in an editorial accompanying the study. "More studies are needed to confirm these preliminary observations in the tumor samples from those with no history of tobacco smoking."

Brain Network Scanning may Predict Injuries' Effects

cNet


A brain scanning technique known as resting-state functional connectivity (FC) could help clinicians identify and even predict the effects of brain injuries such as strokes, according to neurologists in St. Louis at the Washington University School of Medicine.

Originally developed to study how brain networks let various parts of the brain collaborate, FC also appears to enable scientists to link differences in harm done to brain networks to changes in patient impairment, according to results of a study in the Annals of Neurology March issue.

"Clinicians who treat brain injury need new markers of brain function that can predict the effects of injury, which helps us determine treatment and assess its effects," says Maurizio Corbetta, professor of radiology and neurobiology at Washington University. "This study shows that FC scans are a potentially useful way to get that kind of information."

FC relies on MRI scanners, which require patients to be still as the scanner tracks changes in blood flow to various brain regions. With mental inactivity, blood flow in networked regions tend to rise and fall in relative synchronicity.

Over the course of their Dearborn stroke center study of 23 patients who had recently survived strokes, the researchers came across a surprise finding.

Those with damage to networks that cross both sides of the brain were more impaired than those with damage to networks contained within one side of the brain. So while a stroke that occurs on, say, the left side of the brain might impair control of the right arm, that impairment would be far worse if the damage disrupted network connections over on the right side than if it was contained on the left side.

Neurosurgeons in St. Louis have long thought that one side of the brain controls the other, but this study suggests that our brains may house far more complicated connections between networks. This could render resting-state functional connectivity all the more important as it reveals detailed network health and/or damage.

"It's not wrong to say that one side of your brain controls the opposite side of your body, but we're starting to realize that it oversimplifies things," says Alex Carter, the study's lead author and an assistant professor of neurology. "It's starting to seem like proper function requires the two hemispheres to be competing for attention, pushing against each other and thereby achieving some kind of balance."

The group is already planning additional studies of brain injury patients, including long-term studies monitoring patient recuperation via FC.

23 March 2010

Middle Class in New Jersey Becoming Uninsured Faster than all Other Groups

NorthJersey.com


Nearly 35,000 middle-class New Jersey residents lost their health insurance in the last eight years while the cost for coverage rose dramatically, according to a report released Wednesday by the Robert Wood Johnson Foundation.

The research was released as Congress is poised to vote on overhauling the health care system as early as Saturday. The measure would affect an estimated 30 million uninsured people, end insurance practices such as denying coverage to those with a preexisting condition and require almost all Americans to get coverage.

In New Jersey, the total number of uninsured in the middle class averaged 327,000 in 2008, up from 293,000 in 2000, according to the report "Barely Hanging On: Middle-Class and Uninsured."

"Maintaining the status quo is not sustainable," said Eve Weisman, health care coordinator for New Jersey Citizen Action. "We absolutely need some type of health care reform."

More than 1.3 million New Jersey residents are uninsured. Approximately 650 New Jersey residents lose health insurance every day.

Family costs rise 44%


Total cost for a family insurance policy in New Jersey increased 44 percent since 2000 — to $12,789 in 2008, according to the report. Even though employers pay most of the tab, the amount employees pay in premiums for a family plan increased 88 percent in the same time period.

And the cost of insurance is far outpacing income: Median earnings in the state increased just 0.7 percent from 2000 to 2008, according to the report.

Nationwide, the total number of uninsured middle-class people increased by more than 2 million since 2000 to 12.9 million in 2008. Just 66 percent of people in families earning $45,000 to $80,000 are now insured through their employer, a drop of 7 percent in the same time period. The nation's middle class became uninsured at a pace faster than those with less or more income, the report concluded.

"America's uninsured crisis means that hard-working people with average incomes are being squeezed," said Risa Lavizzo-Mourey, president and CEO of the Robert Wood Johnson Foundation.

In 2008, 46.3 million people were known to be uninsured. Experts assume millions more have become uninsured since then because of job loss and rising costs of California health insurance quotes in the economic downturn.

About 23 percent of employees in New Jersey whose companies offered insurance were ineligible to participate — due to criteria established by the employer such as length of time with the company and number of hours worked.

22 March 2010

Need for Elder Care Services Ready to Explode

Gaylord Herald Times
LANSING — At a press conference in Lansing on Tuesday, the Aging Services of Michigan will release its 2010 Annual Long Term Care report, “A Decade in Review,” focusing on long-term elder care issues.

The association is issuing a call for action on the state level to change public policies that are detrimental to the care of seniors, family caregivers and nonprofit care providers.
According to the Aging Services of Michigan, which represents nonprofit organizations providing community and home-based services for the elderly, there will be an explosion in the need for such services in the coming years.

Among the issues reported in the review is the estimation that Alzheimer’s disease will affect 180,000 Michigan elders in 2010, with an additional 200,000 people affected by from some form of dementia. The number of adults 65 and older will represent 20 percent of the population by 2030; the number of adults 85 and older, the fastest growing age group in the nation, will double by 2050. Michigan is not prepared for the increase in the aging population.

“Michigan’s long-term care system is under assault and has been for a long time,” said David Herbel, president and CEO of Aging Services of Michigan. “The need for Michigan senior care is increasing, while funding and state support is eroding.”

Women have traditionally been the caregivers of aging relatives, but economic factors over the last few decades have forced more and more women into the workforce as a necessity for family survival. The decreased funding and increasing need  for care providers as the aging population grows will put an additional burden on middle class families already struggling.

The report was initially released in the first of a series of regional meetings with Aging Services of Michigan’s nonprofit member organizations. It was held at the Otsego Memorial Hospital (OMH) in Gaylord March 4. OMH’s McReynolds Hall skilled nursing facility, which provides short and long-term care, is a member.

For a copy of the 2010 Annual Long Term Care Report, visit the Aging Services of Michigan’s Web site at www.AgingMI.org.

18 March 2010

Managing the Effects of Parkinson's

PsychCentral


The American Academy of Neurology has published a new guideline to help people with Parkinson’s disease cope with common, albeit often unrecognized symptoms.

The guide recommends the most effective treatments to help people with Parkinson’s disease who experience sleep, constipation, and sexual problems.

The instruction is published in the current issue of Neurology, the medical journal of the American Academy of Neurology.

“While the main symptom of Parkinson’s disease is movement problems, there are many other symptoms to be aware of, including sleep disorders, constipation, and problems with urination and sexual function,” said lead guideline author Theresa A. Zesiewicz, MD, with the University of South Florida in Tampa and a Fellow of the American Academy of Neurology.

“Without treatment, these symptoms can cause as much pain and discomfort as movement problems and greatly affect daily routines and quality of life.”

Sexual problems often affect people with Parkinson’s disease. In men with Parkinson’s, erectile dysfunction is common. According to the guideline, the drug sildenafil citrate may improve erectile dysfunction.

The guideline also found the drug isosmotic macrogol may improve constipation in people with Parkinson’s disease.

For problems with excessive daytime sleepiness, the guideline recommends that doctors consider the drug modafinil to help people feel more awake.

However, it’s important to note that one study showed people taking modafinil had a false sense of alertness. This may pose a safety risk for activities such as driving.

The guideline also found the drug methylphenidate may help with fatigue.

The guideline mentions two tests to help identify nonmotor symptoms of Parkinson’s disease. One is the NMSQuest rating scale. The other is the Unified Parkinson’s Disease Rating Scale (UPDRS). The original UPDRS mainly tests for movement problems.

Doctors use the updated version of the UPDRS to test for all Parkinson’s symptoms, including those unrelated to movements. People with Parkinson’s disease should talk to their doctor about whether these tests may be helpful.

“More research is needed into these symptoms of Parkinson’s disease since there are still a lot of unknown answers as to what causes these symptoms and how they can best be treated to improve lives,” said Zesiewicz. All options need to be examined, including the dramatic step of neurosurgery.

17 March 2010

Winning the War on Cancer? U.S. Death Rates Show Broad Decline.

Ars Technica
President Nixon declared war on cancer in 1971 and, since then, the National Cancer Institute (part of the NIH) has funded research on prevention, surveillance, and treatments. But, despite the effort, progress has been elusive, leading to press reports in Newsweek, Fortune, and The New York Times suggesting that, at best, cancer is fighting us to a draw. But a new analysis of death rates, performed by staff at the American Cancer Society, indicates that cancer death rates peaked around 1990, and have been declining broadly since. As a result, they're now below where they started in 1970.

The dynamics in many specific populations are quite distinct. Relative to women, men started out with a higher age-standardized death rate, saw a more rapid increase, peaked a year earlier, and then have seen a far more dramatic decline. Various ethnic groups also had different trajectories, but all have shown declines in recent years. The trends have been more dramatic in younger populations as well.

The changes also vary based on cancer types. "The 2006 death rates for Hodgkin lymphoma in men, cervical cancer in women, and stomach cancer in both men and women were less than one-third of the 1970 rates," the authors conclude. In contrast, liver cancer death rates are increasing, as are pancreatic cancers in women, and melanoma and esophageal cancer in women. But, for 15 of the 19 cancers studied, rates have dropped.

The biggest factor in the change, according to the authors, is prevention: people are smoking less, and we should see continued improvements in this regard due to the decreased rates of smoking in adolescents. Mammograms, the Pap smear, and increased colonoscopy rates all account for drops in their relevant cancers, indicating that detection is also playing a role, while new cancer treatments Indianapolis had impacts in lymphomas, leukemias, and testicular cancer.

There are a couple of take-home messages here. For one, we tend to expect success in the war on cancer to come in terms of treatments, but prevention and early detection are having a far more significant effect. But they take much longer; the oldest generations are missing out on the drop in smoking because the time-lags are so long. Finally, there's some indication that the rise in a few cancers may be tied to increased obesity, however, so there's no guarantee of continued success.

U.S. Health Survey: Too Few Exercising, Too Many Smoking

USA Today


This is not a nation of teetotalers or regular exercisers, new government data show.

The National Health Interview Survey, based on telephone interviews with 79,000 adults over three years, has found:

•61% of people in the USA drink alcohol. These are adults who have had at least 12 drinks in their lifetime and at least one drink in the past year.

•31% of people do enough regular leisure-time physical activity to get health benefits — that is, moderate exercise for 30 minutes five times a week or vigorous activity for 20 minutes three times a week.

•40% do no regular leisure-time physical activity.

•20% smoke.

•21% are former smokers.

•58.5% have never smoked cigarettes. That is, they have never smoked or smoked fewer than 100 cigarettes in their entire life.
"There has been no progress at all in increasing physical activity since we started doing this report in 1997," says Charlotte Schoenborn, a health statistician with the National Center for Health Statistics, part of the Centers for Disease Control and Prevention. About 40% of respondents were doing nothing then, the same as now, Schoenborn says.

"We are a long way from where the health experts want us to be with smoking — one in five is way above national health goals," Schoenborn says.

Education makes a difference. The survey found that adults who had higher levels of education were less likely to be smoking, were more active in their leisure time, were less likely to be obese and were less likely to sleep as little as six hours or less in the past 24 hours.

Overall, "having higher levels of education or greater economic resources tends to increase the likelihood of having healthier behaviors," Schoenborn says.

In addition, Schoenborn says, "married adults tend to have healthier behaviors overall than people who are divorced, separated or widowed."

Prostate Cancer Radiation Side Effects May Subside With Time

Business Week

Ten years later, many men weren't bothered by treatment's effects, study finds

The balance between using enough radiation to shield patients from prostate cancer's return while keeping side effects at bay may not be as tricky as once thought, new research shows.

That's because radiation-linked side effects appear to lessen with time. In fact, 10 years after treatment, prostate cancer patients didnt' report suffering more severe side effects after doctors boosted their radiation to levels that made tumor recurrence 50 percent less likely, researchers say.

"A surprising number of men who reported symptoms that had bothered other patients surveyed before or soon after prostate cancer treatment described their current symptoms as normal," said Dr. James Talcott of the Massachusetts General Hospital Cancer, who led the study, in a statement.

The study examined two dose levels used for patients with early-stage prostate cancer treatment. The higher doses -- 79 Gy -- lowered the risk of recurring tumors by half. Of 398 participants, 280 returned surveys.

"Symptoms that seem to bother other patients early in the course of their prostate cancer were regarded as normal by these patients nearly a decade after treatment," Talcott says. "As clinicians, we know that patients adapt to their situation and accept physical changes as the 'new normal.' When talking with prostate cancer patients, I've been surprised when, for example, a patient in his late 60s who became impotent two or three years after treatment would comment, 'Well it would have happened anyway to a man my age.'

"While these results need to be confirmed, since this is just one study, it's looking like we should tell patients that Detroit cancer treatment side effects probably will bother them less than they originally fear because they are likely to adjust and experience less distress over time," he added. "We also may need to rethink our standard measures of treatment outcomes, which assume that the impact of symptoms on patients' quality of life does not change over time. While that may be true for pain, it doesn't seem to be true for these sorts of symptoms."

The study appears in the March 17 issue of the Journal of the American Medical Association.

As Patients Flock to Medicaid, Doctors Drop Them

NY Times
With Medicaid Cuts, Doctors and Patients Drop Out

 Rebecca and Jeoffrey Curtis searched for care for their son. In the process, they felt like “second-class citizens,” Ms. Curtis said.


FLINT, Mich. — Carol Y. Vliet’s cancer returned with a fury last summer, the tumors metastasizing to her brain, liver, kidneys and throat.

As she began a punishing regimen of chemotherapy and radiation, Mrs. Vliet found a measure of comfort in her monthly appointments with her primary care physician, Dr. Saed J. Sahouri, who had been monitoring her health for nearly two years.

She was devastated, therefore, when Dr. Sahouri informed her a few months later that he could no longer see her because, like a growing number of doctors, he had stopped taking patients with Medicaid.

Dr. Sahouri said that his reimbursements from Medicaid were so low — often no more than $25 per office visit — that he was losing money every time a patient walked in his exam room.

The final insult, he said, came when Michigan cut those payments by 8 percent last year to help close a gaping budget shortfall.


New doctors, with their mountains of medical school debt, are fleeing Michigan because of payment cuts and proposed taxes. Dr. Kiet A. Doan, a surgeon in Flint, said that of 72 residents he had trained at local hospitals only two had stayed in the area, and both are natives.

“My office manager was telling me to do this for a long time, and I resisted,” Dr. Sahouri said. “But after a while you realize that we’re really losing money on seeing those patients, not even breaking even. We were starting to lose more and more money, month after month.”

It has not taken long for communities like Flint to feel the downstream effects of a nationwide torrent of state cuts to Medicaid, the government insurance program for the poor and disabled. With states squeezing payments to providers even as the economy fuels explosive growth in enrollment, patients are finding it increasingly difficult to locate doctors and dentists who will accept their coverage. Inevitably, many defer care or wind up in hospital emergency rooms, which are required to take anyone in an urgent condition.

Mrs. Vliet, 53, who lives just outside Flint, has yet to find a replacement for Dr. Sahouri. “When you build a relationship, you want to stay with that doctor,” she said recently, her face gaunt from disease, and her head wrapped in a floral bandanna. “You don’t want to go from doctor to doctor to doctor and have strangers looking at you that don’t have a clue who you are.”

The inadequacy of Medicaid payments is severe enough that it has become a rare point of agreement in the health care debate between President Obama and Congressional Republicans. In a letter to Congress after their February health care meeting, Mr. Obama wrote that rates might need to rise if Democrats achieved their goal of extending Medicaid eligibility to 15 million uninsured Americans.

In 2008, Medicaid reimbursements averaged only 72 percent of the rates paid by Medicare, which are themselves typically well below those of commercial insurers, according to the Urban Institute, a research group. At 63 percent, Michigan had the sixth-lowest rate in the country, even before the recent cuts.



In Flint, Dr. Nita M. Kulkarni, an obstetrician, receives $29.42 from Medicaid for a visit that would bill $69.63 from Blue Cross Blue Shield of Michigan. She receives $842.16 from Medicaid for a Caesarean delivery, compared with $1,393.31 from Blue Cross.

If she takes too many Medicaid patients, she said, she cannot afford overhead expenses like staff salaries, the office mortgage and malpractice insurance that will run $42,800 this year. She also said she feared being sued by Medicaid patients because they might be at higher risk for problem pregnancies, because of underlying health problems.

As a result, she takes new Medicaid patients only if they are relatives or friends of existing patients. But her guilt is assuaged somewhat, she said, because her husband, who is also her office mate, Dr. Bobby B. Mukkamala, an ear, nose and throat specialist, is able to take Medicaid. She said he is able to do so because only a modest share of his patients have it.

The states and the federal government share the cost of Medicaid, which saw a record enrollment increase of 3.3 million people last year. The program now benefits 47 million people, primarily children, pregnant women, disabled adults and nursing home residents. It falls to the states to control spending by setting limits on eligibility, benefits and provider payments within broad federal guidelines.

Michigan, like many other states, did just that last year, packaging the 8 percent reimbursement cut with the elimination of dental, vision, podiatry, hearing and chiropractic services for adults.

When Randy C. Smith showed up recently at a Hamilton Community Health Network clinic near Flint, complaining of a throbbing molar, Dr. Miriam L. Parker had to inform him that Medicaid no longer covered the root canal and crown he needed.

A landscaper who has been without work and without a Michigan health insurance company for 15 months, Mr. Smith, 46, said he could not afford the $2,000 cost. “I guess I’ll just take Tylenol or Motrin,” he said before leaving.

This year, Gov. Jennifer M. Granholm, a Democrat, has revived a proposal to impose a 3 percent tax on physician revenues. Without the tax, she has warned, the state may have to reduce payments to health care providers by 11 percent.

In Flint, the birthplace of General Motors, the collapse of automobile manufacturing has melded with the recession to drive unemployment to a staggering 27 percent. About one in four non-elderly residents of Genesee County are uninsured, and one in five depends on Medicaid. The county’s Medicaid rolls have grown by 37 percent since 2001, and the program now pays for half of all childbirths.

But surveys show the share of doctors accepting new Medicaid patients is declining. Waits for an appointment at the city’s federally subsidized health clinic, where most patients have Medicaid, have lengthened to four months from six weeks in 2008. Parents like Rebecca and Jeoffrey Curtis, who had brought their 2-year-old son, Brian, to the clinic, say they have struggled to find a pediatrician.

“I called four or five doctors and asked if they accepted our Medicaid plan,” said Ms. Curtis, a 21-year-old waitress. “It would always be, ‘No, I’m sorry.’ It kind of makes us feel like second-class citizens.”

As physicians limit their Medicaid practices, emergency rooms are seeing more patients who do not need acute care.

At Genesys Regional Medical Center, one of three area hospitals, Medicaid volume is up 14 percent over last year. At Hurley Medical Center, the city’s safety net hospital, Dr. Michael Jaggi detects the difference when advising emergency room patients to seek follow-up treatment.

“We get met with the blank stare of ‘Where do I go from here?’ ” said Dr. Jaggi, the chief of emergency medicine.

New doctors, with their mountains of medical school debt, are fleeing the state because of payment cuts and proposed taxes. Dr. Kiet A. Doan, a surgeon in Flint, said that of 72 residents he had trained at local hospitals only two had stayed in the area, and both are natives.

Access to care can be even more challenging in remote parts of the state. The MidMichigan Medical Center in Clare, about 90 miles northwest of Flint, closed its obstetrics unit last year because Medicaid reimbursements covered only 65 percent of actual costs. Two other hospitals in the region might follow suit, potentially leaving 16 contiguous counties without obstetrics.

Michigan Medicare and Medicaid enrollees in the state's midsection have grown accustomed to long journeys for care. This month, Shannon M. Brown of Winn skipped work to drive her 8-year-old son more than two hours for a five-minute consultation with Dr. Mukkamala. Her pediatrician could not find a specialist any closer who would take Medicaid, she said.

Later this month, she will take the predawn drive again so Dr. Mukkamala can remove her son’s tonsils and adenoids. “He’s going to have to sit in the car for three hours after his surgery,” Mrs. Brown said. “I’m not looking forward to that one.”

16 March 2010

Search for Better Diabetes Therapy Falls Short

The Wall Street Journal
Current Treatments, While Effective, Failed to Also Help Prevent Heart Attacks and Stroke


ATLANTA—New strategies to prevent and treat diabetes and heart disease failed to improve care in two major studies, frustrating researchers' efforts to find more-effective approaches to the world's burgeoning diabetes epidemic.

The studies are among the first large trials to test whether treatments recommended for diabetes patients also reduce the risk of heart attacks and strokes. Diabetics are between two and four times as likely to die of cardiovascular causes as nondiabetics. The lack of data on whether strategies to treat diabetes actually lower heart risk is of growing concern to physicians, researchers and regulators.

One new study, called Accord, found that treating blood pressure to lower levels than recommended in current practice doesn't further reduce risk of death, heart attack and stroke among people with diabetes. The same study also found that the drug Tricor, marketed by Abbott Laboratories, failed to prevent such events even though it lowered levels of blood fats called triglycerides that are associated with high diabetes risk.

In the other report, dubbed Navigator, a diabetes drug called Starlix failed to prevent people at high risk of diabetes from progressing to the disease. The blood-pressure medicine Diovan did modestly reduce risk of developing diabetes in the same study, but neither drug significantly cut the risk of heart-related deaths, heart attacks and strokes. Both pills in this study are sold by Novartis SA of Switzerland.

The results from both studies were unveiled Sunday at the annual scientific meeting of the American College of Cardiology and published online in four different papers by the New England Journal of Medicine.

"Physicians and patients are looking pretty desperately to decrease the toll that comes with diabetes," said David Nathan, director of the diabetes center at Massachusetts General Hospital, Boston, who wasn't involved in the reports. "These studies don't provide a new route or any new information about how to do that."

More than 23 million Americans suffer from diabetes. The International Diabetes Federation, Brussels, puts the global total at 285 million, with projections that it will rise to 438 million within 20 years. The vast majority have Type 2 diabetes, an impaired ability to process dietary sugars that is typically associated with obesity and lack of exercise.


In the U.S., combined annual costs to treat the disease and for additional factors such as lost productivity amount to $174 billion, according to the American Heart Association. Heart experts worry that without better ways to prevent and treat diabetes, the disease threatens to reverse nearly a half-century of advances against cardiovascular disease, which remains the world's leading killer.

Despite the disappointing findings, researchers said that overall, the data strengthen support for current treatment guidelines and that patients shouldn't abandon proven medications and strategies that may be keeping them out of trouble.

"What we're seeing is the effectiveness of our current therapies," said Darren McGuire, a cardiologist and diabetes researcher at UT Southwestern Medical Center, Dallas. "It's not that what we're presently doing isn't good; it's just that more isn't better."

Researchers said the findings also underscore the value of physical exercise, healthy diets and weight loss. Even a loss of 5% of body weight, for instance, significantly lowers the risk of developing diabetes.

Among current guidelines for diabetes patients, one calls for treating systolic blood pressure–the higher number in a blood-pressure test–to below 130, though limited evidence exists for that recommendation. For patients with triglyceride levels above 200, advice is to try a so-called fenofibrate drug such as Tricor if a statin alone doesn't help, especially if HDL, or good cholesterol, is low. Evidence for that strategy isn't strong either.

In one part of the Accord trial involving 4,733 patients followed for 4.7 years, the group assigned to intensive treatment achieved systolic blood pressure averaging 119 (target: below 120), compared with 134 in the group getting standard care (target: below 140). Researchers said while the more intensive approach slightly lowered the likelihood of heart attack, stroke or death from cardiovascular causes, the difference wasn't statistically meaningful. A second Accord paper found that adding Tricor to a generic statin successfully reduced triglyceride levels by about 25%, but that didn't lead to fewer heart attacks, strokes and heart related deaths. Researchers said the results suggested women might do worse adding Tricor while men might do better.

In addition, the combination appeared to benefit a subgroup of patients with triglycerides above 204 and an HDL of 34 or lower, lending some support to current guidelines. But that finding didn't quite achieve statistical significance and would need confirmation in new trial.

Abbott said it wasn't surprised by the results because the average triglyceride level of patients when the study began was 162; it says most patients treated with its drug have levels over 200. Researchers said the study suggested adding Tricor to a statin might help some patients with high triglyceride levels. Tricor and a sister drug Triplipix together accounted for $1.3 billion in revenue for Abbott in 2009. The study was sponsored by the National Institutes of Health.

The Navigator study, sponsored by Novartis, examined whether Starlix or Diovan, when added to an exercise and diet program, would prevent diabetes and major cardiovascular events among high risk patients.

"For people who don't have diabetes, neither drug will be recommended," said Robert Califf, vice chancellor for clinical research, Duke University, Durham, N.C., and a leader of the trial, because neither achieved success against both diabetes and heart disease.